David Sinclair

Biografie

Professor und Direktor des Paul F. Glenn Center for the Biology of Aging an der Harvard Medical School

Early career and education

David Sinclair received his Bachelor of Science (BSc) and PhD in Molecular Biology from the University of New South Wales in Sydney, Australia. After completing his studies, he moved to the United States, where he worked at the Massachusetts Institute of Technology (MIT) under the supervision of Leonard Guarente, a pioneer in sirtuin research. This collaboration laid the foundation for Sinclair's future research on NAD+ and sirtuins, proteins that play a key role in cell aging and repair.

Research and discoveries

David Sinclair's research focuses on the role of sirtuins and NAD+ (nicotinamide adenine dinucleotide) in the regulation of longevity and ageing. His work has shown that activating sirtuins by increasing NAD+ levels in cells can slow or even reverse a variety of age-related diseases. These discoveries have revolutionized the understanding of aging processes and opened new avenues for therapeutic approaches.

Sinclair's research has led to important discoveries, including the identification of resveratrol, a compound in red wine that activates sirtuins, and the development of NAD+ precursors such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), which can increase NAD+ levels in the body.

Significance for longevity research and biohacking

David Sinclair has made a significant contribution to longevity research through his research and is considered one of the most influential scientists in this field. His work has not only deepened the scientific understanding of ageing, but has also inspired practical applications in the field of biohacking. Sinclair himself practices many of the techniques he has researched and openly shares his experiences and recommendations.

He is a strong proponent of the idea that aging is a treatable disease and that targeted interventions can significantly improve quality of life and longevity. His books, lectures, and interviews have reached a wide audience and sparked interest in longevity measures and biohacking techniques.

Publications and awards

David Sinclair is the author of numerous scientific articles and books, including the bestseller "Lifespan: Why We Age - and Why We Don't Have To". His work has been published in renowned scientific journals such as "Nature", "Science" and "Cell".

Sinclair has been honored with numerous awards for his outstanding contributions to science, including the TIME 100 Most Influential People Award and the Australian of the Year Award in the science category.